Selected Publications

For a complete list of 87 publications, please visit PubMed.gov. Dr. Zhang’s Google Scholar h-index is 39.

* Corresponding Author

• Wu X *, Wang Z, Croce KR, Li F, Cui J, D’Agati VD, Soni R, Tabas I, Yamamoto A, Zhang H *, Macrophage WDFY3, a protector against autoimmunity. Nature Communications. 2025. In Press.
• Li F *, Flynn E, Ha P, Zebak MN, Cheng, H, Xue C, Shi J, Wu X, Wang Z, Meng Y, Cui J, Zhu Y, Rozenblyum A, Chun J, Hernandez-Ono A, Javaheri A, Razani B, Westerterp M, Bauer RC, Suh Y, Hao K, Lappalainen T, Zhang H *. LIPA, a Risk Locus for CAD: Decoding the Variant-to-Function Relationship. European Heart Journal. 2025 Aug. ehaf581
• Wu X *, Wang Z, Shern T, Zhang H *, Efferocytosis assay to quantify the engulfment and acidification of apoptotic cells by macrophages using flow cytometry. STAR Protocols. 2024 Sep 20;5(3):103215.
• Wu X, Zhang H *. Omics Approaches Unveiling the Biology of Human Atherosclerotic Plaques. Am J Pathol. 2024 Apr;194(4):482-498.
• Chen ZB *, Aikawa E, Alfaidi M, Ali K, Clift CL, Erbay E, Fredman G, Gomez D, Huang NF, Lu HS, Nguyen PK, Darc Oliveira S, Rodriguez-Miguelez P, SenthilKumar G, Zhang H *. Institutional Support for the Career Advancement of Women Faculty in Science and Academic Medicine: Successes, Challenges, and Future Directions. Arterioscler Thromb Vasc Biol. 2024 Jul 3.
• Li F, Zhang H *. Targeting Epsins to reverse atherosclerosis. Circ Res, 2023;132:7–9.
• Shi J,# Wu X,# Wang Z, Li F, Meng Y, Moore RM, Cui J, Xue C, Croce KR, Yurdagul Jr A, Doench JG, Li W, Zarbalis KS, Tabas I, Yamamoto A, Zhang H *, A Genome-wide CRISPR Screen Identifies WDFY3 as a Regulator of Macrophage Efferocytosis. Nature Communications. 2022 Dec 24;13(1):7929. PMID: 36566259.
• Shi H, Wang X, Li F, Gerlach1 BD, Yurdagul, Jr. A, Moore M, Zeldin S, Zhang H, Cai B, Zheng Z, Valenti L, Tabas I. CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis. Science Translational Medicine. 2022 Nov 23;14(672):eabp8309. PMID: 36417485.
• Bi X, Stankov S, Lee PC, Wang Z, Wu X, Li L, Ko YA, Cheng L, Zhang H, Hand NJ, Rader DJ. ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors. Arterioscler Thromb Vasc Biol. 2022 Sep;42(9):1139-1151; PMID: 35861973.
• Zhang H *, Wolf D *. Break on Through to the Other Side: How Trained Monocytes Promote Recovery From Hind Limb Ischemia. Arterioscler Thromb Vasc Biol. 2021 Dec 23;ATVBAHA121317257.
• Zhang H *, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen PKP, Ouimet M, Sutton NR, Aikawa E. What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2641-2647.
• Miller, CL *, Zhang H *. Clarifying the distinct roles of smooth muscle cell-derived vs macrophage foam cells and the implications in atherosclerosis. Arterioscler Thromb Vasc Biol. 2021. 41 (6), 2035-2037.
• Kasikara C, Schilperoort M, Gerlach BD, Xue C, Wang X, Zheng Z, Kuriakose G, Dorweiler B, Zhang H, Fredman G, Saleheen D, Reilly MP, Tabas I. Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis. J Clin Invest. 2021 Feb 25:145275. doi: 10.1172/JCI145275. PMID: 33630758
• Pan H, Xue C, Auerbach BJ, Fan J, Bashore AC, Cui J, Yang DY, Trignano SB, Liu W, Shi J, Ihuegbu CO, Bush EC, Worley J, Vlahos L, Laise P, Solomon RA, Connolly ES, Califano A, Sims PA, Zhang H, Li M, Reilly MP. Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human. Circulation. 2020 Sep 23. doi: 10.1161/CIRCULATIONAHA.120.048378. PMID: 32962412
• Li F, Shi J, Lu HS, Zhang H*. Functional Genomics and CRISPR Applied to Cardiovascular Research and Medicine. Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):e188-e194.
• Li F, Zhang H*. Lysosomal Acid Lipase in Lipid Metabolism and Beyond. Arterioscler Thromb Vasc Biol. 2019 May;39(5):850-856.
• Shi J, Xue C, Liu W, Zhang H*. Differentiation of Human Induced Pluripotent Stem Cells to Macrophages For Disease Modeling and Functional Genomics. Current Protocols in Stem Cell Biology. 2019 Feb;48(1):e74.
• Westerterp M, Fotakis P, Ouimet M, Bochem AE, Zhang H, Molusky MM, Wang W, Abramowicz S, la Bastide-van Gemert S, Wang N, Welch CL, Reilly MP, Stroes ES, Moore KJ, Tall AR. Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis and Atherogenesis. Circulation. 2018 Aug 28;138(9):898-912.
• Zhang H*. Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies. Curr Opin Lipidol. 2018 Jun;29(3):218-223.
• Zhang H*, Reilly M *. Who done it? Macrophage Mayhem in Atherosclerosis. Circulation Research. 2018 Oct 26;123(10):1106-1108.
• Zhang H*, Xue C, Wang Y, Shi J, Zhang X, Li W, Nunez S, Foulkes AS, Lin J, Hinkle CC, Yang W, Morrisey EE, Rader DJ, Li M, and Reilly MP *. Deep RNA-sequencing uncovers a repertoire of human macrophage lincRNAs that is modulated by macrophage activation and associates with cardiometabolic diseases. J Am Heart Assoc. 2017 Nov 13;6(11).
• Zhang H*, Shi J, Hachet MA, Xue C, Bauer RC, Jiang H, Li W, Tohyama J, Millar J, Billheimer J, Phillips MC, Razani B, Rader DJ, Reilly MP. CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2156-2160.
• Nurnberg ST, Zhang H, Hand NJ, Bauer RC, Saleheen D, Reilly MP and Rader DJ. From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circulation Research. 2016;118:586-606.
• Zhang H, Xue C, Shah R, Bermingham K, Hinkle CC, Li W, Rodrigues A, Tabita-Martinez J, Millar JS, Cuchel M, Pashos EE, Liu Y, Yan R, Yang W, Gosai SJ, VanDorn D, Chou ST, Gregory BD, Morrisey EE, Li M, Rader DJ, Reilly MP. Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease. Circulation Research. 2015 Jun 19;117(1):17-28.